Solubility and Dissolution Rate Enhancement of Olmesartan Medoxomil by Complexation and Development of Mouth Dissolving Tablets

The main objective of the research work is to improve the solubility and dissolution rate of olmesartan medoxomil by complexation with -Cyclodextrins. The inclusion complexes were prepared by kneading method. The prepared complexes were characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD) and Differential Scanning Calorimetry (DSC). The FTIR and XRD spectra of olmesartan/ -Cyclodextrins solid complexes showed that olmesartan medoxomil could form inclusion complex with -Cyclodextrins in solid state. The XRD spectra of olmesartan/ -Cyclodextrins solid complexes indicated olmesartanmedoxomilexisted in amorphous state, this could be explained the fact that the aqueous solubility of olmesartan medoxomil was increased. From the prepared inclusion complexes, fast dissolving tablets were formulated by using various superdisintegrants like sodium starch glycolate and croscarmellosesodium in various concentrations (5-15%).Prepared tablets were evaluated for physical parameters and drug release by invitro dissolution studies. Dissolution studies showed fast release of olmesartan medoxomil in tablets containing a high level of sodium starch glycolate. Complexation of olmesartan medoxomil with -CD significantly improved the solubility of the drug and improved the mechanical properties of tablets produced by direct compression.